Clinical Case Reports for the Evidence-Based Era

Breast asymmetry after oncoplastic or reconstructive surgery has an adverse aesthetic effect and psychological, significantly reducing the quality of life. The contralateral breast symmetry procedure not only makes it possible to achieve a good aesthetic effect; removing part of the parenchyma of the healthy breast reduces the risk of the appearance of an independent, metachronous cancer in it in the future, as well as finding asymptomatic cancer of low grade during histopathological examination of the preparation.

As defined, erectile dysfunction (ED, erectile dysfunction) is the persistent inability to achieve and/or maintain an erection sufficient for satisfactory sexual activity (symptoms must persist for a minimum of three months, unless ED is associated with trauma or surgery surgery). It is estimated that 3 million men in Poland are affected, and in a population with cardiovascular disease (CVD, or Cardiovascular Disease) it affects nearly 80% of patients.

The use of dose-dense or "dense-dose" complementary chemotherapy in early breast cancer has allowed significantly improve the four-year disease-free survival (DFS) rate, especially in a group of patients who are young and have the so-called triple-negative (tripple nega􀆟ve) breast cancer phenotype. This mode of administration of chemotherapy is associated with a significantly higher (about 20%) risk of neutropenic fever (GN). As part of primary prophylaxis, current standards use granulocyte colony-stimulating agents granulocyte colony-stimulating agents, mainly the long-acting form - pegfilgrastim. Recently, a new long-acting G-CSF - lipegfilgrastim.

Rare disease affects less than 1 person/2000 population. To date, 6,000 rare diseases have been detected. Each person is a carrier of 5-10 genes for rare diseases (mostly recessive genes). The rarity of of these diseases usually leads to a delay in making a correct diagnosis, sometimes by many years.