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Peer-reviewed clinical case reports

№ 99Internal MedicineCase ReportOpen Access
Intrauterine growth restriction in the course of Silver-Russell syndrome - a case report

Intrauterine growth restriction in the course of Silver-Russell syndrome - a case report

<p>Intrauterine fetal growth restriction (IUGR) is one of the most serious complications of pregnancy. It affects an average of 8% of live-born newborns in developed countries, and up to 15-20% in developing countries[1, 2, 3].</p><p>It is associated with an increased rate of intrauterine deaths and pregnancy complications, including preterm deliveries and perinatal deaths. In children, abnormalities in psychophysical development and a higher incidence, including in adulthood, of conditions such as obesity, diabetes, and metabolic syndrome are observed[1, 2, 7, 8 , 9]. IUGR refers to the inability of the fetus to reach its full growth potential during intrauterine life [4, 5, 6]. Many times the term hypotrophy is used interchangeably. According to most authors, IUGR is diagnosed when two ultrasound measurements of the fetus show excessively slow growth rates and/or when birth weight/length is less than 2 SD ( standard deviations), or 10th percentile relative to gestational age. In severe forms, birth weight or AC ( abdominal circumference) correspond to values below the 3rd Centile. [6, 8]. The etiology of intrauterine growth retardation is multifactorial, and despite advances in medicine, it is often, even in 40%, impossible to identify . We distinguish maternal causes ( among others.: hypertension, kidney disease, cardiovascular disease, diabetes mellitus, thrombophilias, antiphospholipid syndrome, genetic factors, drugs), fetal(mainly genetic abnormalities, congenital malformations, intrauterine infections, metabolic blocks), placental (abnormalities in placental structure and capacity, pre-eclampsia), environmental (low socioeconomic status of the mother, stimulants, nutritional deficiencies) [1, 9, 10, 11, 12].</p><p>The management of suspected IUGR should include a thorough general medical and obstetric history, assessment of risk factors to identify pregnant women requiring enhanced surveillance, and detailed imaging and laboratory tests. Ultrasonography of the fetus (evaluation of anatomy, size , proportion, growth dynamics) is the primary diagnostic test. It is also necessary to monitor fetal well-being with cardiotocography (ktg), assessment of blood flow in selected vessels ( usg doppler), amniotic fluid volume and biophysical profile. Appropriate laboratory tests are performed to confirm or exclude maternal chronic diseases, intrauterine infections, pre-eclampsia, HELLP syndrome and other pregnancy pathologies that may affect growth disorders [12,13]. In the absence of a clear cause leading to IUGR, genetic testing is important. Maternal genes are believed to have a major impact on the baby's birth weight. However, also many chromosomal aberrations in the fetus are associated with intrauterine growth retardation [6, 12]. An example is Silver- Russell syndrome (SRS), which varies widely in the type of genetic alterations present and how they are inherited. Mutations affect chromosome 11, 7, among others, and are associated with characteristic phenotypic features, which include primarily bone lesions in the form of : scoliosis, limb length disproportion, toe fusion, elbow joint lesions. According to the literature, between 1:50,000 and 1:100,000 children are born with this syndrome [14, 15, 16].</p><p>The main goal of maternal and child care in pregnancy complicated by intrauterine fetal growth retardation is to ensure and strictly assess fetal well-being and to choose the optimal delivery date [6, 12].</p>.

Received 16 Dec 2016Accepted 08 May 2017Published 13 Aug 2017
JI
Jagielska I., Kaźmierczak J., Maćkowiak K.13 Aug 2017
№ 98SurgeryCase ReportOpen Access
Tongue cancer diagnosed incidentally in a patient with anaemia and joint pain.

Tongue cancer diagnosed incidentally in a patient with anaemia and joint pain.

Tongue cancer is the most common oral cancer [1]. Most patients report exposure to known risk factors for cancer development, such as frequent alcohol consumption, smoking, and poor oral hygiene [1, 2]. Unfortunately, due to the tumor's location and patients' failure to appreciate early symptoms, most diagnoses are made in very advanced stages of the disease [2]. We present a case report of a patient with incidentally diagnosed tongue cancer.

Received 26 May 2016Accepted 08 Jul 2016Published 03 Jul 2017
CO
Chrabański O., Gibińska J., Onyszczuk M.03 Jul 2017
№ 97GynecologyCase ReportOpen Access
Paraganglioma in a 41-years old woman: a rare neoplasm of the retroperitoneal space

Paraganglioma in a 41-years old woman: a rare neoplasm of the retroperitoneal space

<p>Paraganglioma(Latin: paraganglioma) is a rare, mostly benign neuroendocrine tumor originating from the paraventricular bodies of the parasympathetic and sympathetic nervous systems. The 2013 National Cancer Registry did not find any data on the incidence of this tumor in Poland [1]. The histopathological structure and symptoms of the tumor often resemble pheochromocytoma. It can be said that pheochromocytoma is a special type of chaperone tumor. Chaperones originating from the parathyroid bodies of the parasympathetic nervous system are usually located near the large vessels of the head and neck (bifurcation of the common carotid artery-the most common location) [2], while chaperones from the sympathetic nervous system chaperones occur along the sympathetic trunk located adjacent to the vertebral column, abdominal aorta and inferior vena cava [even aortic glomerulus (Zuckerkandel's organ) lying on either side of the aorta, just above its bifurcation-the most common location].</p><p>Parenomas are neoplasms of old age, with peak incidence in the 5th and 6th decades of life. In about 10% of cases, they occur familially, being part of such genetically determined syndromes as [3]:</p><p>- von Hippel-Lindau syndrome</p><p>- multiple endocrine adenocarcinoma syndrome types 2A and 2B</p><p>- Carney syndrome</p><p>Diagnosis of chaperones is not straightforward, as these tumors are rare. In cases where the tumor is hormonally active, there are symptoms associated with high levels of catecholamines in the blood (accelerated heart rate, increased blood pressure, hot flashes, headaches). When a hormonally active tumor is absent, symptoms may result from tumor growth in a specific location (dull pain in the lumbar region). Most often, however, chaperones are diagnosed incidentally in a neck or abdominal and pelvic ultrasound performed for other reasons or as an annual prophylaxis (the tumor diagnosis is then confirmed on CT).</p><p>Tumor fine-needle biopsy is unlikely to be performed due to the rich vascularization of the tumor and the associated risk of bleeding.</p><p>Because of the rarity of chaperones, there are no established diagnostic and therapeutic algorithms.</p><p>Treatment consists of surgical removal of the tumor. In cases where the location of the tumor does not allow surgical removal, radiation therapy is applicable.</p><p></p><p>Rocalization is generally very good. If the tumor is completely removed, the cure is complete.</p>

Received 05 Mar 2017Accepted 18 Apr 2017Published 19 Apr 2017
BP
Bobik P., Kowal P., Dąbrowska K.19 Apr 2017
№ 96GynecologyCase ReportOpen Access
A foreign body in the chest

A foreign body in the chest

Patients with pneumothorax constitute a significant percentage of all hospitalizations in general surgery departments. Pneumothorax can be spontaneous, most often caused by pulmonary emphysema, or post-traumatic, primarily resulting from chest wall contusion. A specific type of pneumothorax is the iatrogenic variety, which can generally be classified as post-traumatic.

Received 17 Sept 2016Accepted 17 Feb 2017Published 09 Mar 2017
KB
Kalbarczyk B., Kalbarczyk B., Rojewski R.09 Mar 2017
№ 95SurgeryCase ReportOpen Access
Severe scabies misdiagnosed as allergic reaction after kidney transplantation.

Severe scabies misdiagnosed as allergic reaction after kidney transplantation.

Due to immunosuppressive therapy, paƟents who underwent organ allotransplantaƟon are more likely to present an unusual clinical manifestaƟon of frequent everyday diseases. We present an uncommon case of Scabies in the renal transplanted recipient.

Received 23 Dec 2016Accepted 17 Feb 2017Published 06 Mar 2017
HW
Hajdusianek W., Hryncewicz-Gwóźdź A., Boratyńska M.06 Mar 2017

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