Publications

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome resulting from an exaggerated inflammatory reaction. HLH can be triggered by a variety of congenital and acquired factors. The most common symptoms of HLH are persistent fever, splenic enlargement and cytopenias in the peripheral blood. Laboratory findings include hyperferritinemia (often >10000 μg/L) and elevated levels of soluble receptor for interleukin-2. Without appropriate treatment, HLH leads usually to the death of the patient.

In children, the main cause of diabetes is type 1 diabetes.Other types of diabetes found in children can be type 2 diabetes and other specific causes of diabetes such as drug-induced diabetes, diabetes accompanying cystic fibrosis, or diabetes caused by a defect in a single gene (type 3).

Tumors were detected in a 59-year-old male long-term smoker with no significant past medical history of both lungs. A bronchoscopy was performed, which showed bronchial stenosis on the right side to segment 9 by a submucosal infiltration. Cytological examination of the brush biopsy smear and histopathological examination of the sections from the lesion yielded a diagnosis of squamous cell carcinoma. Due to the equivocal nature of the left lung lesion on CT scan, a PET-CT was performed. The result of the study: SUVmax of right lung cancer = 1.9; left lung tumor = 8.8.It was decided to perform thoracotomy left-sided thoracotomy. An ad hoc intraoperative cytological examination of the left lung tumor impression revealed non-small cell carcinoma cells. The lower lobe was removed along with the mediastinal lymph nodes. After two months, a video-guided right lower lobectomy with mediastinal lymphadenectomy was performed. Histopathological examination of the right lung revealed pre-invasive squamous cell carcinoma while the left lung was diagnosed as squamous cell carcinoma with an intermediate grade of cell differentiation (G2). Taking into account the criteria of Martini and Melamed, bilateral synchronous foci of of primary cancer.

The case of a 29-year-old patient with a late diagnosed mediastinal abscess is presented. The symptom that drew attention to this possibility was a left-sided pneumothorax. Two weeks earlier, the patient had had an inflamed mandibular sixth molar removed. On the day of admission, alveolar hemorrhage occurred. An ad hoc revision of the alveolus, and tooth VII was removed. The neck abscess was incised. Pleural drainage was obtained to expand the lung. In the further course, massive alveolar hemorrhages occurred a couple of times. Repeat alveolar revisions and three times the branches of the external carotid artery were surgically supplied. The last operation was followed by a massive hemorrhage. As it was determined - from the mediastinum. By means of an emergency sternotomy an aortic lesion at the left carotid artery outlet was visualized, which was sutured. The mediastinitis was controlled with drainage and antibiotics, achieving a cure.

Platelet rich plasma (PRP - Platelet Rich Plasma) is a concentrated volume of platelets dispersed in a small volume of plasma containing platelet-rich growth factors, used based on the based on the concept of orthobiologics. The strategy for using PRP is to use the patient's own blood as a a means of stimulating the regenerative processes of both soft tissue and bone tissue

Malignant tumors of the testicle are rare cancers - they account for only 1.5% of all malignancies malignant neoplasms, however, they are the most common solid tumor in 25-40 year old men. They constitute a diverse histologically a group of diseases. Most are characterized by high malignancy and an aggressive clinical course clinical course, and are usually sensitive to chemotherapy and radiotherapy.

Kidney cancer accounts for about 3% of all malignant tumors. It mainly affects patients 60-70 years old, more often men than women. The mainstay of treatment is nephrectomy, and renal artery embolization is used as palliative therapy. Combined treatment uses immunotherapy and modern targeted therapy.

Cystadenocarcinoma is a rare malignant liver tumor that arises de novo or from benign lesions of the nature of cystadenocarcinomas. Symptoms are nonspecific and include: pain in the right upper quadrant of the abdominal cavity, a feeling of discomfort or fullness, jaundice, weight loss and are related related to the size of the lesion. The recommended treatment is resection of the lesion along with a margin of healthy tissue.

One of the indications for liver transplantation is primary malignancies. Among adults, the most common is hepatocellular carcinoma, while among children embryonal hepatoma predominates. In addition, it has been noted the existence of tumors with intermediate characteristics between the two.

In HPV infections, a very important and underestimated clinical aspect is the co-occurrence of lesions in different locations and the ease of transmission between sexual partners. Also of significant clinical importance is vertical infection during pregnancy, which can lead to infection of the fetus. Virus-induced papillomas can develop in any part of the upper and lower respiratory tract as well as in the upper gastrointestinal tract. They most often occupy the larynx, and also develop in the tonsils, trachea, bronchi and lungs, and can also show aggressive growth and undergo malignant transformation.

An abnormally implanted placenta previa is one of the leading causes of hemorrhage in the perinatal period, posing a threat to the life of the mother and fetus.

Renal failure occurs in about one-third of patients with acute heart failure and in about 25-40% of patients with chronic heart failure. Damage to one of these organs can secondarily lead to abnormal function of the other, which underlies the pathophysiology of CRS cardiac-renal syndrome.